FLT3 INHIBITION UPREGULATES OCT4/NANOG TO PROMOTE MAINTENANCE AND TKI RESISTANCE OF FLT3-ITD+ ACUTE MYELOID LEUKEMIA

FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia

Abstract Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due to the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation.Although FLT3 inhibitors show encouraging outcomes in treatment, they fail to eliminate leukemia stem cells, the origin of persistent and resistant lesions.Exploration

read more

The educational curriculum in a book that is remembered by the speaker in the literature of the world and the learner

Before I talk about this book, I hasten to say: What prompted me to write Ready Meals about this topic is the place of this initiative to eradicate illiteracy that will save many souls from the claws of ignorance that the shadows of knowledge will shed over them.Ignorance has its flaws, and those who are armed with it are armed with a free-range we

read more

Heaven and the Goodness of God

In this essay, I argue that we should take fully seriously the doctrine of heaven when dealing with the problem of evil in our world.The hope of heaven is integral to Christian theism so it cannot be neglected in any substantive discussion of athletic-shirts the problem of evil.Indeed, heaven provides resources to respond to even the worst of evils

read more